Pycnogenol counteracts kidney damage due to hyprtension...

Pycnogenol® is the patented trade name for a water extract of the bark of the French maritime pine (Pinus pinaster ssp. atlantica), which is grown in coastal southwest France.  Pycnogenol® contains oligomeric proanthocyanidins (OPCs) as well as several other bioflavonoids (catechin, epicatechin), phenolic fruit acids (such as ferulic acid and caffeic acid), and taxifolin. Procyanidins are oligometric catechins found at high concentrations in red wine, grapes, cocoa, cranberries, apples, and some supplements such as Pycnogenol.

Scientific evidence on its antioxidative capacity and protective action on the vascular system have been published in the most renowned scientific journals. Additional published findings have demonstrated Pycnogenol’s beneficial effects in cardiovascular health (reduces LDL), skincare (e.g., Melasma, erythema, Chronic venous insufficiency), cognitive function, diabetes health, inflammation, sports nutrition, asthma and allergy relief and menstrual disorders, among others.

Earlier research suggested that, supplementation of Pycnogenol® with  conventional diabetes treatment may lower glucose levels and improve endothelial function and may improve symptoms associated with diabetic microangiopathy.

Now researchers lead by Dr. Gianni Belcaro, have come up with an interesting finding.i.e.,  Pycnogenol®  counteracts kidney damage caused by hypertension, lowering urinary proteins and improving blood flow to the kidneys.

The randomized, controlled study conducted by the G D'Annunzio University in Italy investigated 55 hypertensive patients who showed early signs of impaired kidney function, as judged by elevated amounts of proteins found in their urine.  The patients were divided into two groups.  Both groups were treated with anti-hypertensive medication Ramipril and one group of 29 patients took Pycnogenol in addition to the Ramipril.

After six months of treatment with Ramipril, average protein levels decreased to 64 mg per 24-hour period, remaining well above an acceptable level.  Conversely, the group taking Pycnogenol® as an adjunct to Ramipril had an average of only 39 mg per 24-hour period, a decrease of nearly double compared with anti-hypertensive medication taken alone.

The study also found a statistically significant decrease in patients' blood pressure when taking Pycnogenol® in conjunction with Ramipril.  As per the clam by the researchers, the addition of Pycnogenol® decreased both systolic and diastolic pressures by an additional three to six percent.  Pycnogenol® was also found to lower the patients' elevated levels of inflammatory marker CRP, a blood protein associated with the risk for acute cardiovascular events such as heart attack, reducing values to a healthy level.

Researchers conclude that, Pycnogenol® as an adjunct to the medication produced significantly greater results, particularly for kidney function restoration  and Pycnogenol® continues to demonstrate its abilities as a natural solution for the complete cardiovascular system....

Ref :  Dr. Gianni Belcaro et.al., March 2010, Journal of Cardiovascular Pharmacology...

Study shows maritime pine bark extract may be effective in limiting muscle loss due to aging

In continuation of my update on Pycnogenol....

A new peer-reviewed, published study shows French maritime pine bark extract, Pycnogenol®, may be effective in curbing muscle loss that occurs with aging – a natural process that leads to sarcopenia, a common condition affecting adults as early as age 65. The study, published in the September 2016 Journal on Orthopedics and Traumatology, revealed that daily supplementation with Pycnogenol® helps to stabilize muscles through this natural process and supports muscular function and endurance.

 

According to the National Library of Medicine, physically inactive individuals can lose as much as eight percent of muscle mass each decade after 30. Those who are physically active can maintain more muscle mass yet are still affected by muscle loss due to aging.

"Muscle loss due to aging can affect even the most active individuals and can result in feelings of weakness and frustrating fatigue which can interfere with our daily activities. This natural process is why opening a jar of pickles gets harder as we get older. We have less muscle to work with, so our muscles must work harder and, thus, we get tired faster," said nationally-known natural nutrition expert Dr. Fred Pescatore.

"This new study builds on a body of research connecting Pycnogenol® to healthy aging," said Dr. Pescatore. "As we age, muscle loss starts to impact the daily activities we tend to take for granted like climbing stairs, lifting groceries or enjoying walks without getting tired. This research shows that Pycnogenol can help alleviate the symptoms of sarcopenia and can support muscle function as we age."

In the study, participants between ages 70 - 78 and exhibiting symptoms of muscle loss, sarcopenia and fatigue but otherwise healthy, reported feeling increased muscle endurance in completing daily tasks such as walking and stair climbing, and improved overall muscular function by more than 40 percent. After just 8 weeks of taking 150 mg of Pycnogenol® the study results showed:

"What I found really compelling is the measurable effect Pycnogenol® had on the participants in relation to completing daily tasks -- the research shows that Pycnogenol® can play a role in helping you stay active with greater muscular stability and maintain muscle function as you age," Dr. Pescatore noted.

While experts recommend adequate amounts of sleep, in addition to diet and daily exercise to maintain physical fitness in later years, the study results are encouraging for those looking for an added boost in muscle function overall.

Ref : http://www.webmd.com/vitamins-supplements/ingredientmono-1019-pycnogenol.aspx?activeingredientid=1019