Mechanism of synthesizing estrogen visualized.....

Dr. Ghosh lab, has determined the structures of all three of the enzymes (aromatase, sulfatase and 17beta-hydroxysteroid dehydrogenase type 1) involved in controlling estrogen levels that can serve as drug targets for estrogen-dependent tumors in breast cancer. It s really interesting now as the structures of all three key enzymes implicated in estrogen-dependant breast cancers are known, one can have the drugs those can target these three enzymes. Hope with the help of molecular modelling, the goal to have a personalized cocktail of inhibitors customized to the specific treatment needs of each patient can be achieved in the days to come. Hats off to Dr.Ghosh and co workers and wish them to achieve the next target i.e., chemical mechanism involved in the conversion of androgens to estrogens. Once they achieve the next target, hope we will have more Aromatase inhibitor drugs with reduced side effects.....