A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease. The drug, known as J147 (above structure), improved memory and prevented brain damage
caused by the disease claims the researchers from Salk's Cellular Neurobiology Laboratory, lead by David Schubert. The new compound, could be tested for treatment of
the disease in humans in the near future.Researchers add that, J147 enhances memory in both normal and Alzheimer's mice and also protects the brain from the loss of synaptic connections.
Salk researchers went on to show that it prevented cognitive
decline in animals with Alzheimer's and that mice and rats treated with
the drug produced more of a protein called brain-derived neurotrophic
factor (BDNF), a molecule that protects neurons from toxic insults,
helps new neurons grow and connect with other brain cells, and is
involved in memory formation.
Because of the broad ability of J147 to protect nerve cells, the
researchers believe that it may also be effective for treating other
neurological disorders, such as Parkinson's disease, Huntington's
disease and amyotrophic lateral sclerosis (ALS), as well as stroke.
Although it is yet unknown whether the compound will prove safe and
effective in humans, the Salk researchers' say their results suggest the
drug may hold potential for treatment of people with Alzheimer's...
Ref : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027865
Ref : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027865
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