Data will be presented during three poster sessions at the Association for Research in Vision and Ophthalmology (ARVO) annual meeting in Fort Lauderdale, Florida. NovaBay's Aganocide compounds are first-in-class anti-infectives being developed for the treatment and prevention of antibiotic-resistant infections. NovaBay and Alcon, Inc., the world's leading eye care company, have a licensing and research collaboration agreement for the use of NovaBay's Aganocide compounds in the eye, ear and sinus, and for contact lens care.
The three presentations are :
1. Dichloro analog (AL-46383A) (see structure) as a Novel Topical Ophthalmic Agent, 2. In vitro evaluation of dichloro analog as an Antiviral Agent Against Adenovirus and HSV-1 and 3. topical dichloro analog, Inhibits Adenovirus Replication in the Ocular Ad5/NZW Rabbit Replication Model.
NVC-422, or AL-46383A, is a stable compound based on the chemical structures of N-chlorotaurine (NCT) and N,N-dichlorotaurine, which are naturally occurring antimicrobial agents produced by the body's white blood cells to fight invasive pathogens.
Alcon is conducting a Phase 2 clinical trial of this compound for the treatment of viral conjunctivitis, a form of "pink eye". The randomized, placebo-controlled trial is enrolling approximately 250 patients at more than 30 medical centers in the United States and worldwide. It is designed to determine the safety and efficacy of NVC-422 or AL-46383A.
Ref : http://www.novabaypharma.com/investors/release/apr_30_2010
