Smoking May Increase Odds of Meniere Disease in Men

For men, smoking is positively related and alcohol consumption is negatively related to the risk for Meniere disease (MD), according to a study published online Aug. 26 in the Journal of Clinical Medicine.

So Young Kim, Ph.D., from the CHA University in Seongnam, South Korea, and colleagues examined the association of smoking, alcohol consumption, and obesity with MD among the population older than 40 years of age in the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2019. A total of 15,208 MD patients were matched with 499,658 controls.

The researchers found that in the overall adult population, there was no association for smoking and alcohol consumption with MD. The odds of MD were lower in association with being underweight (adjusted odds ratio, 0.80; 95 percent confidence interval, 0.68 to 0.93; P = 0.004). Smoking was positively associated with MD in men, while there was a negative association observed for alcohol consumption with MD (adjusted odds ratios, 1.08 [95 percent confidence interval, 1.00 to 1.17; P = 0.043] and 0.87 [95 percent confidence interval, 0.81 to 0.94; P < 0.001], respectively).

"The current study improved previous knowledge on the associated factors of MD by concurrently assessing multiple lifestyle factors, including smoking, alcohol consumption, and obesity," the authors write. "As these are modifiable factors, lifestyle modifications can be clinically valuable management strategies for patients who suffer from MD."

Ref : For men, smoking is positively related and alcohol consumption is negatively related to the risk for Meniere disease (MD), according to a study published online Aug. 26 in the Journal of Clinical Medicine.

So Young Kim, Ph.D., from the CHA University in Seongnam, South Korea, and colleagues examined the association of smoking, alcohol consumption, and obesity with MD among the population older than 40 years of age in the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2019. A total of 15,208 MD patients were matched with 499,658 controls.

The researchers found that in the overall adult population, there was no association for smoking and alcohol consumption with MD. The odds of MD were lower in association with being underweight (adjusted odds ratio, 0.80; 95 percent confidence interval, 0.68 to 0.93; P = 0.004). Smoking was positively associated with MD in men, while there was a negative association observed for alcohol consumption with MD (adjusted odds ratios, 1.08 [95 percent confidence interval, 1.00 to 1.17; P = 0.043] and 0.87 [95 percent confidence interval, 0.81 to 0.94; P < 0.001], respectively).

"The current study improved previous knowledge on the associated factors of MD by concurrently assessing multiple lifestyle factors, including smoking, alcohol consumption, and obesity," the authors write. "As these are modifiable factors, lifestyle modifications can be clinically valuable management strategies for patients who suffer from MD."

Ref : Smoking May Increase Odds of Meniere Disease in Men 

Drug May Help Women Who Quit Smoking Avoid Weight Gain - Drugs.com MedNews

In continuation of my update on Naltrexone

We know that, Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. It is marketed in generic form as its hydrochloridesalt, naltrexone hydrochloride, and marketed under the trade names Revia andDepade. In some countries including the United States, a once-monthly extended-release injectable formulation is marketed under the trade name Vivitrol. Also in the US, Methylnaltrexone Bromide, a closely related drug, is marketed as Relistor, for the treatment of opioid induced constipation.

Naltrexone should not be confused with naloxone (which is used in emergency cases of overdose rather than for longer-term dependence control) nor nalorphine. Using naloxone in place of naltrexone can cause far worse withdrawal symptoms; conversely, using naltrexone in place of naloxone in an overdose can lead to insufficient opiate antagonism and fail to reverse the overdose.

Drug May Help Women Who Quit Smoking Avoid Weight Gain - Drugs.com MedNews