Top-line results from Pfizer's tofacitinib Phase 3 studies in RA

In continuation of my update on drugs discovery on  rheumatoid arthritis, 

Top-line results from Pfizer's tofacitinib Phase 3 studies in RA..

Melatonin can help fight obesity and risks associated with it

Melatonin can help fight obesity and risks associated with it

Idera's gene-silencing oligonucleotide studies published in Journal of Medicinal Chemistry

In continuation of my update on antisense drugs and nucleotides

Idera's gene-silencing oligonucleotide studies published in Journal of Medicinal Chemistry

Ref : JMC 

Scientists Exploit Ash Tree Pest's Chemical Communication....

A newly identified chemical sex attractant, or pheromone, of the emerald ash borer could mean improved traps for monitoring and controlling the tree-killing beetle. That's the goal of U.S. Department of Agriculture (USDA) entomologist Allard Cossé and his colleagues. 

More recently, the team discovered a macrocyclic lactone (3z-dodecan-12-olide -see structure), a compound that female borers release while feeding. Large-scale field tests conducted in Canada and the United States showed that the compound attracts male borers and has potential for use in traps either alone or combined with ash-tree-based attractants, reports Cossé, at the ARS National Center for Agricultural Utilization Research in Peoria, Ill........

ARS : News

Details in a book 

Soy food does not increase risk of recurrence or death among breast cancer survivors

In continuation of my update on Soy food...

Soy food does not increase risk of recurrence or death among breast cancer survivors

New substance (Benzothiazin derivative) to tackle drug resistant tuberculosis...

Project NM4TB which gathers 18 research teams from 13 countries, discovered a novel class of substances, called benzothiazinones (BTZ-see structure), that could be used in the treatment of tuberculosis and drug resistant tuberculosis.

Prof Stewart Cole, Dr Vadim Makarov, Dr Ute Möllmann, Prof Giovanna Riccardi, and their colleagues have identified a novel class of compounds called benzothiazinones (BTZ) that act by preventing the TB bacterium from constructing its cell wall. In particular, one member of the class, BTZ043 was extremely potent, killing the TB agent, both in test tube experiments and in mouse models of the disease. BTZ043 is as effective as the two main drugs (Isoniazid and Rifampicin) in reducing the bacterial levels in the lungs and spleens of infected mice. The target of the new class of compounds is a component of Mycobacterium’s cell-wall-building machinery that has never before been used as a drug target. The most advanced compound of this new class, BTZ043, is a candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant TB. 

These substances act by preventing the bacteria that cause tuberculosis from constructing their cell wall. This discovery represents an important breakthrough in the battle against tuberculosis as the most advanced compound of this new class, BTZ043, is also effective against extensively drug resistant tuberculosis (XDR-TB).

More... : 

Strawberries for prevention of esophageal cancer: Study

In continuation of my update on benefits of strawberries.....
Strawberries for prevention of esophageal cancer: Study

New drug shrinks cancer in animals, U-M study shows | University of Michigan Health System

New drug shrinks cancer in animals, U-M study shows | University of Michigan Health System

AstraZeneca receives FDA approval for vandetanib to treat medullary thyroid cancer

In continuation of my update on Vandetanib,,,,,
AstraZeneca receives FDA approval for vandetanib to treat medullary thyroid cancer

Vismodegib is an effective treatment for patients with basal cell carcinomas

 Vismodegib :


Vismodegib is an effective treatment for patients with basal cell carcinomas

Maple syrup contains a range of antioxidant compounds not found in other sweeteners

In continuation of my update on Maple syrup...

Maple syrup contains a range of antioxidant compounds not found in other sweeteners

Thalidomide provides new hope for patients with difficult to treat liver cancer

Thalidomoide

Thalidomide provides new hope for patients with difficult to treat liver cancer

Researchers identify drug candidate that can treat prostate cancer

Drug candidate, developed from a naturally occurring anti-cancer agent found in cruciferous vegetables such as cabbages and broccoli, for prostate cancer...
Researchers identify drug candidate that can treat prostate cancer

Boceprevir drug can help cure hard-to-treat hepatitis C

In continuation of my update on Boceprevir...
Boceprevir drug can help cure hard-to-treat hepatitis C

Thirty four new beneficial compounds found in pure maple syrup

In continuation of my update on maple syrup....
Thirty four new beneficial compounds found in pure maple syrup